Method of Improving Skin Appearance

ABSTRACT

A skin care kit is provided. The skin care kit has a cosmetic composition having an effective amount of a skin active agent and one or more barrier patches. The barrier patch has a backing layer having a first surface and a pressure sensitive adhesive in contact with the first surface. The barrier patch also has an adhesive release force of about 50 gms to about 400 gms; a flexibility of about 8 grams to about 40 grams; and a WVTR of about 1 g/m 2 /24 h to about 500 g/m 2 /24 h. The kit also includes a display package with a display surface.

TECHNICAL FIELD

The present invention relates to method of delivering cosmeticcompositions to a target area of the skin via the use of a barrierpatch. The barrier patch comprises a backing layer and a pressuresensitive adhesive. The barrier patch has improved properties thatprovide greater comfort in use, long lasting adhesion, ease of removal,more efficient delivery of skin care agents to the skin, and thataffords greater formulation flexibility.

BACKGROUND OF THE INVENTION

The benefits of using a patch or mask device comprising skin agents tocosmetically treat the skin, have been recognized in the art. Cosmeticpatches or devices are commercially marketed or described as beinguseful for the delivery of skin care actives. Patches have also beendescribed in the literature and marketed in the medical field as auseful means for the transdermal administration of drugs.

However, many patches or devices suffer drawbacks in their physicalproduct forms resulting in undesirable in-use characteristics asperceived by the wearer. For example, some patches are too wet orsticky. A patch and/or device that comprises gel forming agents may notform a solid gel structure and as a result, are difficult to handle andapply to the skin. Other patches are dry, rough, and inflexible and thusare tight and uncomfortable to wear. These patches often do not conformwell to the contours of the skin surface to which they are applied. Somepatches or devices, on the other hand, are too flexible. These patchesare thus difficult to handle and apply and may actually conform tooclosely to the contours of the skin emphasizing wrinkles or eveninducing wrinkles. Some patches and devices are difficult to remove andleave behind residue after removal due to their high adhesive and/orcohesive properties.

Moreover, patches and devices are also known where the active agents areincorporated into the adhesive materials in the patch. Thus thesepatches serve as a delivery substrate for the actives. Incompatibilitybetween the skin agents and the adhesive materials may result inineffective partitioning of the skin agents through the adhesive layer.This may lead to inferior penetration of the skin agents into the layersof the skin. Thus some patches or devices also do not provide aneffective release and penetration of skin care benefit agents.

Consumers desire products that provide targeted skin care effectiveness.These products often require more complex regimens which may require theuse of multiple components such as one or more liquid compositions andother implements that deliver the composition to target areas of theskin most needing treatment. For the beauty-conscious consumer, a normaldaily routine may include the use of 4 to 8 different products everymorning and evening. While products with multiple components mayincrease the complexity of the beauty regimen, on the other hand theymay provide more customized and targeted treatment and thus enhanceoverall efficacy for each unique consumer.

Also, skin care manufacturers want to provide skincare packages thatwill give consumers the most effective, solution-oriented, enjoyable andconvenient experience when using a product. Complex regimens may impactcompliance, and the lack of compliance of the beauty regimen can lead topoor overall product performance and lower overall consumerdissatisfaction. Thus skin care packaging must ensure that theseproducts with complex regimens are easy and convenient to use. Skincarepackaging also needs to effectively communicate all of the features andbenefits of the product such as effectiveness, immediate results,quality, and ease of use.

It has now been found that a user's satisfaction may be improved byrebalancing the properties of the barrier patch. By selecting the properdegree of flexibility, adhesive strength for ease of removal, occlusionand permeability, skin active agents are effectively delivered to theskin, and a superior in use experience is provided for the consumer.Furthermore, some of the embodiments herein allow greater formulationflexibility, for example, by allowing the incorporation of a broaderrange of skin active agents, which would otherwise interact with theadhesive material.

In addition there is a need to reduce the complexity of the normal dailyskin care routine while improving overall compliance and consumersatisfaction for targeted skin care regimens and products. Therefore afunctional and aesthetically acceptable product and package that issuitable for simplifying beauty regimens is provided herein.

SUMMARY OF THE INVENTION

In accordance with one embodiment, a method of treating skin is providedcomprising:

a. applying a cosmetic composition to a target area of the skin,comprising an effective amount of a skin active agent, in an embodimentthe skin active agent is provided as a separate component from a barrierpatch;b. applying the barrier patch to the target area of skin, the barrierpatch comprising a backing layer having a first surface; a pressuresensitive adhesive in contact with the first surface; adjusting theproperties of the barrier patch to have: an adhesive release force ofabout 50 gms to about 400 gms; a WVTR from about 1 g/m²/24 h to about500 g/m²/24 h; in another embodiment from about 1 g/m²/24 h to about 180g/m²/24 h and a flexibility from about 8 grams to about 40 grams.

In an embodiment the cosmetic composition is maintained in contact withthe target area of skin via the barrier patch, for a period of time fromabout 2 hours to about 1 week and/or from about 2 hours to about 12hours.

In accordance with another embodiment, a method of treating skin isprovided comprising:

a. applying a cosmetic composition to a target area of the skin,comprising an oil in water emulsion with an effective amount of a skinactive agent that is provided as separate component from a barrierpatch;b. applying the barrier patch comprising:

a backing layer having a first surface;

a pressure sensitive adhesive in contact with the first surface;

adjusting the properties of the barrier patch to have:

-   -   an adhesive release of from about 75 gms to about 350 gms;    -   a WVTR from about 1 g/m²/24 h to about 180 g/m²/24 h;    -   a flexibility from about 8 grams to about 25 grams.

In accordance with another embodiment, a method of treating skin isprovided comprising:

a. applying a cosmetic composition to a target area of the skin,comprising an effective amount of a skin active agent that is providedas separate component from a barrier patch;b. applying the barrier patch comprising:

a backing layer having a first surface;

a pressure sensitive adhesive in contact with the first surface;

adjusting the properties of the barrier patch to have:

-   -   an adhesive release force of about 50 gms to about 400 gms;    -   a WVTR from about 1 g/m²/24 h to about 500 g/m²/24 h;    -   a flexibility from about 8 grams to about 40 grams; and        adjusting the barrier patch to provide a hydration value of        about 35 to about 120.

In further embodiments, a skin care kit is provided comprising:

a cosmetic composition comprising an effective amount of a skin activeagent;a barrier patch comprising a backing layer having a first surface and apressure sensitive adhesive in contact with the first surface; thebarrier patch comprising an adhesive release force of from about 50 gmsto about 400 gms; a flexibility from about 8 grams to about 40 grams;and a WVTR from about 1 g/m²/24 h to about 500 g/m²/24 h;a display package comprising:

a display surface or an inclined display surface, defining a firstcavity to contain the cosmetic composition and a second cavity tocontain a plurality of barrier patches.

In another embodiment the display package further comprises a top coverhaving a front wall, a back wall and two sidewalls; a base having afront wall, a back wall and two sidewalls; an intermediate surroundwindow positioned between said top cover and said base. The cosmeticcomposition may either be positioned substantially within the firstcavity or positioned in an upright position in the first cavity. Theedges of the front wall, back wall and two sidewalls of the top covermay be configured to mate with the edges of the front wall, back walland two sidewalls of the base when the intermediate surround window isremoved to provide a close fitting relationship.

The cosmetic compositions in any of the embodiments of this summary maycomprise an aqueous cosmetic composition.

BRIEF DESCRIPTION OF THE DRAWINGS

While the specification concludes with claims that particularly pointout and distinctly claim the invention, it is believed that the presentinvention will be better understood from the following description ofembodiments, taken in conjunction with the accompanying drawings inwhich:

FIG. 1 is a perspective view of a barrier patch, as shown and describedherein.

FIG. 2 is a top plan view of the barrier patch of FIG. 1, as shown anddescribed herein.

FIG. 3 is a cross section of an alternative barrier patch, as shown anddescribed herein.

FIG. 4 is a perspective side view of an embodiment of the displaypackage.

FIG. 5 is a perspective side view of another embodiment of a displaypackage.

FIG. 6 is a perspective side view of another embodiment of a displaypackage.

FIG. 7 is a perspective side view of another embodiment of a displaypackage.

FIG. 8 is a graph showing the effect of occlusion on skin hydration.

DETAILED DESCRIPTION OF THE INVENTION

While the specification concludes with the claims particularly pointingout and distinctly claiming the invention, it is believed that thepresent invention will be better understood from the followingdescription.

All percentages and ratios used herein are by weight of the totalcomposition and all measurements made are at 25° C., unless otherwisedesignated. All numeric ranges are inclusive of narrower ranges;delineated upper and lower range limits are interchangeable to createfurther ranges not explicitly delineated.

The compositions of the present invention can comprise, consistessentially of, or consist of, the essential components as well asoptional ingredients described herein. As used herein, “consistingessentially of” means that the composition or component may includeadditional ingredients, but only if the additional ingredients do notmaterially alter the basic and novel characteristics of the claimedcompositions or methods.

The term “apply” or “application” as used in reference to a composition,means to apply or spread the compositions of the present invention ontoa substrate such as the human skin surface or epidermis.

The term “dermatologically acceptable,” as used herein, means that thecompositions or components thereof so described are suitable for use incontact with mammalian keratinous tissue without undue toxicity,incompatibility, instability, allergic response, and the like.

The term “facial skin surface” as used herein refers to one or more offorehead, periorbital, cheek, perioral, chin, and nose skin surfaces.While facial skin surfaces are of concern and are exemplified herein,other skin surfaces may be treated with the compositions and methods ofthe present invention, for example, surfaces typically not covered byclothing such as facial skin surfaces, hand and arm skin surfaces, footand leg skin surfaces, and neck and chest skin surfaces (for example,déolletage).

The term “keratinous tissue,” as used herein, refers tokeratin-containing layers disposed as the outermost protective coveringof mammals (for example, humans, dogs, cats, etc.) which includes, butis not limited to, skin, mucosa, lips, hair, toenails, fingernails,cuticles, hooves, etc.

The terms “topical application”, “topically”, and “topical”, as usedherein, mean to apply (for example, spread, spray) the compositions ofthe present invention onto the surface of the keratinous tissue.

As used herein, “effective amount” means an amount of a compound orcomposition sufficient to significantly induce a positive keratinoustissue benefit, including independently or in combination with otherbenefits disclosed herein. This means that the content and/orconcentration of agent in the formulation is sufficient that when theformulation is applied with normal frequency and in a normal amount, theformulation can result in the treatment of one or more undesiredkeratinous tissue conditions (for example, skin wrinkles). For instance,the amount can be an amount sufficient to inhibit or enhance somebiochemical function occurring within the keratinous tissue. This amountof the skin care agent may vary depending upon the type of product, thetype of keratinous tissue condition to be addressed, and the like.

The term “safe and effective amount” as used herein means an amount of acompound or composition sufficient to significantly induce a positivebenefit, preferably a positive keratinous tissue appearance, includingindependently or in combinations with the benefits disclosed herein, butlow enough to avoid serious side effects, i.e., to provide a reasonablebenefit to risk ratio, within the scope of sound judgment of the skilledartisan.

As used herein, “transparent” or “visibly clear” is defined as havingthe property of transmitting light without appreciable scattering sothat bodies lying behind are perceivable. One acceptable test method fordetermining whether a product is clear or transparent is according tothe method provided herein.

The term “translucent”, as used herein may include “frosted”,“glittered”, “pearlescence” and the like and is defined herein as thepractice of inducing a low level of light scattering into an otherwise“clear” material causing the material to become matted in appearance.

As used herein, the term “water impermeable” includes materials orobjects through which water in its liquid state does not pass.

Barrier Patch

In an embodiment a skin care product or kit is provided hereincomprising a cosmetic composition comprising an effective amount of askin active agent and a barrier patch comprising a backing layer havinga first surface and a pressure sensitive adhesive in contact with thefirst surface; the barrier patch comprising an adhesive release force offrom about 50 gms to about 400 gms; a flexibility from about 8 grams toabout 40 grams; and a WVTR from about 1 g/m²/24 h to about 500 g/m²/24.

In an embodiment the method may comprise:

a. applying a cosmetic composition to a target area of the skin,comprising an effective amount of a skin active agent;b. applying a barrier patch to the target area of skin, the barrierpatch comprising:

a backing layer having a first surface;

a pressure sensitive adhesive in contact with the first surface;

adjusting the properties of the barrier patch to have:

-   -   an adhesive release force of about 50 gms to about 400 gms; a        WVTR of about 1 g/m²/24 h to about 500 g/m²/24 h; and a        flexibility of about 8 grams to about 40 grams.

An exemplary embodiment of the barrier patch 1 is shown in FIGS. 1 and2. The barrier patch comprises a backing layer 2 and a pressuresensitive adhesive 3. The backing layer has a first surface 5 and asecond surface 6. The pressure sensitive adhesive 3 is in contact withat least part of the first surface 5 of the backing layer 2 to form apressure sensitive adhesive coated region 7 of the first surface 5. Inthe embodiment of FIGS. 1 and 2, the barrier patch 1 is rectangular,however this shape is not intended to limit the invention.

A cross section of another exemplary embodiment of a subject barrierpatch is shown in FIG. 3 and includes a backing layer 10, a pressuresensitive adhesive 11, and a release layer 12.

The backing layer of the barrier patch of the present invention maycomprise a solid sheet material. The sheet provides the primarystructure and shape to the patch, allowing it to be handled and appliedfor treatment of a specific target area of the skin.

The barrier patches have a size and shape adapted to conform to adesired target area of skin which could be a human face or part thereof,legs, hands, arms, feet, or human torso. They may be generally flat inappearance.

The exact size and shape of the barrier patch will depend upon theintended use and product characteristics. The barrier patch herein canbe, for example, a square, circle, semicircle, rectangle, triangle,oval, ring, crescent, crescent with rounded corners, teardrop or othermore complex and irregular shape. The shape of the barrier patch may beselected from the group consisting of circle, square, rectangle,triangle, and/or irregular shape that conforms to the contours of theforehead, perioral, and/or periorbital areas of the human face.

For a barrier patch shaped to fit the face or other target area of skin,the surface area of the barrier patch may range from about 0.25 cm² toabout 1000 cm², and/or from about 1 cm² to about 500 cm², and/or fromabout 1 cm² to about 200 cm², and/or from about 1 cm² to about 50 cm²,and/or from about 5 cm² to about 15 cm². Surface area refers to that ofa flat plane having the same boundary as the surface i.e. ignoring anysurface texturing present.

In an embodiment, the barrier patch typically has an average thicknessranging from about 0.5 mils to about 100 mils, in alternativeembodiments the barrier patch has a thickness of about 1 mils to about35 mils and/or about 2 mils to about 30 mils and/or an average thicknessof from about 3 mils to about 15 mils.

In certain embodiments the barrier patch is substantially free of,comprises only non-effective amounts of, or is void of, a skin activeagent. As such, the barrier patch of the present invention may becharacterized as a “blank” barrier patch. In this regard, in anembodiment an effective amount of the skin active agent employed is aseparate component from the barrier patch.

In certain embodiments, the barrier patch comprises a backing layer.According to one embodiment, the barrier patch or backing layer is afilm having a WTVR value between about 1 g/m²/24 h to about 500 g/m²/24h, and in another embodiment has a WVTR from about 1 g/m²/24 h to about250 g/m²/24 h and/or from about 1 g/m²/24 h to about 180 g/m²/24 hand/or from about 2 g/m²/24 h to about 150 g/m²/24 h and/or from about 2to about 20 g/m²/24 h. The term WTVR stands for “Water VaporTransmission Rate” and is measured according to the methods herein.

The backing layer in certain embodiments is non-porous or impermeable towater. Thus in an embodiment the barrier patch or backing layer is waterimpermeable. In certain other embodiments the backing layer isimpermeable to the cosmetic composition, the skin care active agentemployed, and fluids wherein the WVTR is from about from about 2 toabout 100 g/m²/24 h. While not being bound by theory using a substratethat prevents water loss from the cosmetic composition while thecosmetic composition is in contact with the keratinous tissue and skin,prevents the cosmetic composition from drying out. Water loss from thecosmetic composition may lower the water concentration, may destabilizean emulsion if present, and may increase the concentration of skinactive agents. This may result in reduced or loss of efficacy and/orirritation to the skin.

Such relative water impermeability and lower water vapor permeability ofthe backing layer and barrier patch may increase the effectiveness andefficiency of the cosmetic composition used with the barrier patch. Forexample, without being bound by theory, the water impermeability andlower water vapor permeability of the backing layer and/or barrier patchemployed may serve to enhance or increase the penetration of the skincare active agent into the skin.

In certain embodiments the liquid-impermeable and breathable backinglayer and barrier patch may, for example, consist of a perforatedpolyethylene film, where the size of the holes has been chosen so thatair and vapor may pass, but not liquid molecules. Breathable materialscan, as mentioned above, consist of perforated plastic films. Oneexample of such film is described in U.S. Pat. No. 5,628,737. Thebacking layer may also consist of micro-porous plastic films, as isdescribed in, for example, EP-A-0238200.

In one embodiment the barrier patch is polyethylene film sold under thetradename, 1525L, available from 3M, St. Paul, Minn. No. 1525-L has abacking of polyethylene film of approximately 3 mil thickness, a 1.4 milthick hypoallergenic, pressure sensitive acrylate adhesive layer and apaper release layer coated with polyethylene and silicone.

In certain embodiments, the backing layer is generally made of aflexible material which is capable of remaining fitted and flexingduring the movement of the human body and movements associated withfacial expressions or gestures. By “flexible” it is meant that thebacking layer may be substantially bent or folded without breaking,tearing, ripping, etc. The barrier patch comprises a flexibility fromabout 8 grams to about 40 grams and/or about 8 grams to about 25 grams,and/or from about 10 grams to about 25 grams, and/or from about 2 gramsto about 10 grams. This degree of flexibility of the barrier patch isselected in combination with the thickness, WVTR, and adhesion releaseproperties, to ensure that desirable conformability and comfort areobtained. The barrier patch also does not collapse or fold under gravityor upon handling and application by the user. It is desirable for thebarrier patch to conform to the target area of the skin surface to whichit is applied without folding, crinkling, or inducing more wrinkling ofthe target area of the skin. Accordingly, the barrier patch is readilyconformable to the skin and remains flexible throughout the duration ofuse, as the user moves during the period of time worn. In an embodiment,the flexibility is substantially constant for the entire period of timethat the barrier patch is worn by the user.

Since the thickness of the barrier patch will influence flexibility, thesubstrate thickness should be selected that enables the desiredflexibility of the barrier patch to be achieved.

The backing layer of the barrier patch may comprise at least onematerial, for example, a water impermeable and water vapor permeablematerial, that includes but is not limited to polypropylene (PP);polyethylene (PE, including HDPE and LLDPE); polyethylene terephthalate(PET); polyvinylchloride (PVC); polyamide (PA); polycarbonate;polyurethane; cellulose acetate; polychloropene; polysulfone;polytetrafluoroethylene (PTFE); polyvinyl acetate (PVA); polyethyleneglycol terephthalate film; polystyrene; polyphenylene oxide (PPO);acrylonitrile butadiene styrene (ABS); acrylic; acrylonitrile styreneacrylate (ASA); ethylene vinyl alcohol (EVA); natural rubber, latex,nylon, nitrile, silicone and thermo plastic elastomers (TPE), andcombination thereof. The backing layer may comprise a single polymer ormixtures of polymers or copolymers. The barrier patch may comprise apolyolefin, and/or a high density polyethylene. Laminates of thesematerials may also be used. The materials also may be coextruded. In oneembodiment the backing layer or barrier layer is substantially free of anon-woven material.

In one embodiment, to provide for a less visible and less conspicuousbarrier patch, the barrier patch is transparent, translucent, and/orvisibly clear. One acceptable test method for determining whether aproduct is clear or transparent is according to the method providedherein which determines the transparency threshold. In one embodimentthe barrier patch is transparent and in other embodiment the barrierpatch has a transparency threshold from about 1 point to about 10 point,and/or about 1 point to about 4 point, and/or no greater than about 10point, and/or no greater than about 4 point.

The cosmetic composition and barrier patch, for example, may remain incontact with the target area of skin for a period of time from about 2hours to about 1 week. Once the period of time has elapsed, the barrierpatch is removed by peeling it away from the target area of the skin sothat upon removal, the barrier patch is removed intact, i.e., no backinglayer material is left on the target area of the skin.

The balance of properties of the barrier patch enables it to be easilyand non-traumatically removed from the target area of skin. In certainembodiment the adhesive release force is from about 50 grams to about400 grams, in another embodiment is from about 75 grams to about 350grams, and in another embodiment is from about 100 grams to about 200grams. If the adhesive release force is too low, then the patch does notremain adhered to the target area of skin for the full extended wearingtime. If the adhesive release force is too high, the removal of thepatch at the end of the wearing period is either painful or is traumaticto the skin. The method of determining the adhesive release force isaccording to the method herein.

Without being bound by theory, occlusion from the barrier patch servesthree important purposes. First, by maintaining a continuously moistenvironment on the skin, the composition such as an aqueous compositioncomprising skin active agents can be kept in a liquefied or solubilizedform to create a sustained delivery environment compared to traditionalgel or lotion carriers alone that become dried on skin. Also, greaterhydration/water content in the skin can promote a more favorablethermodynamic/physical environment to enable increased penetration andflux of some actives through layers of the skin, thereby increasing thedelivery rate or amount of actives residing in the skin. Finally,building a reservoir of moisture in the skin serves to plump or swellthe skin structure.

Therefore in one embodiment the method and compositions herein providefor improved hydration of the target area of skin. As show in FIG. 8,and according to the Methods provided herein, the hydration of thetarget area of skin after 8 hours was from about 35 to about 120 and/orfrom about 38 to about 100 and/or about 40 to about 95 and/or about 45to about 95. In FIG. 8, A is 3M 2476, B is 3M Medipore H, C is 3M 1525Land D is 3M 9830.

The barrier patch may be manufactured by any suitable method, includingcasting, injection moulding, co-injection moulding, over moulding,in-mold assembly, compression moulding, blow moulding, casting thermo orvacuum forming. Where appropriate the barrier patch may be laminated byheat welding (which may further include the use of pressure, ultrasonicforces and radio or high frequencies), co-extrusion; adhesives, electrostatic adhesions (such as flocking by fibres) and topical surfaceapplications.

A variety of adhesives may be used in the manufacture of the barrierpatch herein. Typically, the adhesive material is a pressure-sensitiveadhesive (PSA) that is suitable for long-term skin contact, and whichshould be physically and chemically compatible with the backing layerand/or additives that are present. Examples of suitable adhesivematerials include, but are not limited to, the following: acrylic andmethacrylic ester homo- or copolymers, butyl rubber based systems,silicones, urethanes, vinyl esters and amides, olefin copolymermaterials, natural or synthetic rubbers, hot-melt adhesives (see, forexample, U.S. Pat. No. 5,387,450); polyethylenes; polysiloxanes;polyisobutylenes; polyacrylates; polyacrylamides; polyurethanes;plasticized ethylene-vinyl acetate copolymers; and tacky rubbers such aspolyisobutene, polybutadiene, polystyrene-isoprene copolymers,polystyrene-butadiene copolymers, and neoprene (polychloroprene) andcombinations thereof.

The adhesive typically has an average thickness ranging from about 0.5mils to about 15 mils, in alternative embodiments about 1 mils to about5 mils.

In accordance with one embodiment, a method of making a barrier patch isprovided comprising:

a. laminating a barrier patch by a process selected from the groupconsisting of heat welding, ultrasonic force, co-extrusion, adhesion,electro static adhesion and combinations thereof; the barrier patchhaving a first surface;b. applying a pressure a pressure sensitive adhesive to the firstsurface;the barrier patch having an adhesive release force of about 50 gms toabout 400 gms; a WVTR from about 1 g/m²/24 h to about 500 g/m²/24 h; inanother embodiment from about 1 g/m²/24 h to about 180 g/m²/24 h and aflexibility from about 8 grams to about 40 grams.

Release Layer

The barrier patch herein may further comprise a protective release layerremovably attached to the pressure sensitive adhesive side, for example,first surface, of the backing layer and opposite the second surface ofthe backing layer. The release layer provides protection for thepressure sensitive adhesive from the environment and prior toapplication by the user.

The protective release layer may comprise materials including polymerresins such as polyolefins, for example, polypropylene (includingstratified biaxially oriented polypropylene (SBOPP)), polyethylene(including LDPE; LLDPE; HDPE; Metallocene) or polyethyleneterephthalate, and combinations thereof. Alternative materials which maybe used include polyvinylchloride, polyamide, acetyl, acrylonitrilebutadiene styrene, acrylic, acrylonitrile styrene acrylate, ethylenevinyl alcohol, ethylene vinyl acetate, Nylon, Latex, natural orsynthetic rubbers, polycarbonate, polystyrene, silicone or thermoplastic elastomer, thermo plastic vulcanate or copolymers of saidmaterials, and combinations thereof. In an embodiment the protectiverelease layer may comprise a coating of a non-stick material. Exemplarynon-stick coatings include wax, silicone, fluoropolymers such asTEFLON®, and fluorosilicones.

In an embodiment, the protective release layer covers the entireaforementioned area of pressure sensitive adhesive coated region of thebacking layer. In another embodiment the protective release layer iswater impermeable. In a further embodiment, the release layer has a meanthickness of at least about 85 microns, or from about 85 microns toabout 150 microns, and/or from about 90 microns to about 120 microns.

The release layer may optionally extend, in whole or part, beyond thepressure sensitive adhesive coated region of the backing layer and/orbeyond the backing layer to provide a removal tab that facilitates easeof removal of the release layer.

Cosmetic Composition Skin Active Agents

The compositions of the present invention may comprise a skin activeagent which provides a particular skin care benefit characteristic ofthe usage of the skin care product. The skin care benefit may includebenefits related to appearance or make-up of the skin. The skin careactive can provide acute (immediate and short lived) benefits, orchronic (long term and longer lasting) benefits.

The term “skin active agent” as used herein, means an active ingredientwhich provides a cosmetic and/or therapeutic effect to the area ofapplication on the skin. The skin active agents useful herein includeskin lightening agents, anti-acne agents, emollients, non-steroidalanti-inflammatory agents, topical anaesthetics, artificial tanningagents, anti-microbial and anti-fungal actives, skin soothing agents,sun screening agents, skin barrier repair agents, anti-wrinkle agents,anti-skin atrophy actives, lipids, sebum inhibitors, sebum inhibitors,skin sensates, protease inhibitors, anti-itch agents, desquamationenzyme enhancers, anti-glycation agents, and mixtures thereof. Whenincluded, the present composition comprises a safe and effective amountof a skin active agent and/or from about 0.001% to about 20%, in anotherembodiment from about 0.1% to about 10% of at least one skin activeagent.

The type and amount of skin active agents are selected so that theinclusion of a specific agent does not affect the stability of thecomposition. For example, hydrophilic agents may be incorporated in anamount soluble in the aqueous phase, while lipophilic agents may beincorporated in an amount soluble in the oil phase.

Other skin active agents purported to exhibit expression-line relaxingbenefits for use in the present invention include, but are not limitedto, Lavandox available from Barnet Products Corporation; Thallasine 2,available from BiotechMarine; Argireline NP, available from Lipotec;Gatuline In-Tense and Gatuline Expression, available from Gattefosse;Myoxinol LS 9736 from BASF Chemical Company, Syn-ake, available from DSMNutritional Products, Inc.; and Instensyl®, available from Silab, Inc;Sesaflash™, available from Seppic Inc.

Skin lightening agents useful herein refer to active ingredients thatimprove hyperpigmentation as compared to pre-treatment. Useful skinlightening agents herein include ascorbic acid compounds, vitamin B₃compounds, azelaic acid, butyl hydroxyanisole, gallic acid and itsderivatives, glycyrrhizinic acid, hydroquinone, kojic acid, arbutin,mulberry extract, and mixtures thereof. Use of combinations of skinlightening agents is believed to be advantageous in that they mayprovide skin lightening benefit through different mechanisms.

Ascorbic acid compounds useful herein include ascorbic acid per se inthe L-form, ascorbic acid salt, and derivatives thereof. Ascorbic acidsalts useful herein include, sodium, potassium, lithium, calcium,magnesium, barium, ammonium and protamine salts. Ascorbic acidderivatives useful herein include, for example, esters of ascorbic acid,and ester salts of ascorbic acid. Particularly preferred ascorbic acidcompounds include 2-o-D-glucopyranosyl-L-ascorbic acid, which is anester of ascorbic acid and glucose and usually referred to as L-ascorbicacid 2-glucoside or ascorbyl glucoside, and its metal salts, andL-ascorbic acid phosphate ester salts such as sodium ascorbyl phosphate,potassium ascorbyl phosphate, magnesium ascorbyl phosphate, and calciumascorbyl phosphate. Commercially available ascorbic compounds includemagnesium ascorbyl phosphate available from Showa Denko,2-o-D-glucopyranosyl-L-ascorbic acid available from Hayashibara andsodium L-ascorbyl phosphate with tradename STAY C available from Roche.

Vitamin B₃ compounds useful herein include, for example, those havingthe formula:

wherein R is —CONH₂ (for example, niacinamide) or —CH₂OH (for example,nicotinyl alcohol); derivatives thereof; and salts thereof. Exemplaryderivatives of the foregoing vitamin B₃ compounds include nicotinic acidesters, including non-vasodilating esters of nicotinic acid, nicotinylamino acids, nicotinyl alcohol esters of carboxylic acids, nicotinicacid N-oxide and niacinamide N-oxide. Preferred vitamin B₃ compounds areniacinamide and tocopherol nicotinate, and in another embodiment isniacinamide. In a preferred embodiment, the vitamin B₃ compound containsa limited amount of the salt form and is more preferably substantiallyfree of salts of a vitamin B₃ compound. Preferably the vitamin B₃compound contains less than about 50% of such salt, and is morepreferably essentially free of the salt form. Commercially availablevitamin B₃ compounds that are highly useful herein include niacinamideUSP available from Reilly.

Other hydrophobic skin lightening agents useful herein include ascorbicacid derivatives such as ascorbyl tetraisopalmitate (for example, VC-IPavailable from Nikko Chemical), ascorbyl palmitate (for example,available from Roche Vitamins), ascorbyl dipalmitate (for example,NIKKOL CP available from Nikko Chemical); undecylenoyl phenyl alanine(for example, SEPIWHITE MSH available from Seppic); octadecenedioic acid(for example, ARLATONE DIOIC DCA available from Uniquema); oenotherabiennis sead extract, and pyrus malus (apple) fruit extract, Water andMyritol 318 and butylene glycol and tocopherol and sscorbiltetraisopalmitate and Paraben and Carbopol 980 and DNA/SMARTVECTOR UVavailable from COLETICA, magnesium ascorbyl phosphate in hyaluronicfilling sphere available from COLETICA, and mixtures thereof.

Other skin active agents useful herein include those selected from thegroup consisting of N-acetyl D-glucosamine, panthenol (for example, DLpanthenol available from Alps Pharmaceutical Inc.), tocopherylnicotinate, benzoyl peroxide, 3-hydroxy benzoic acid, flavonoids (forexample, flavanone, chalcone), farnesol, phytantriol, glycolic acid,lactic acid, 4-hydroxy benzoic acid, acetyl salicylic acid,2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid,cis-retinoic acid, trans-retinoic acid, retinol, retinyl esters (forexample, retinyl propionate), phytic acid, N-acetyl-L-cysteine, lipoicacid, tocopherol and its esters (for example, tocopheryl acetate:DL-α-tocopheryl acetate available from Eisai), azelaic acid, arachidonicacid, tetracycline, ibuprofen, naproxen, ketoprofen, hydrocortisone,acetominophen, resorcinol, phenoxyethanol, phenoxypropanol,phenoxyisopropanol, 2,4,4′-trichloro-2′-hydroxy diphenyl ether,3,4,4′-trichlorocarbanilide, octopirox, lidocaine hydrochloride,clotrimazole, miconazole, ketoconazole, neomycin sulfate, theophylline,and mixtures thereof.

The compositions of the present invention in various embodiments maycomprise N-acyl amino acid compounds. Suitable N-acyl amino acidcompounds include, but are not limited to, N-acyl phenylalanine, N-acyltyrosine, their isomers, including their D and L isomers, salts,derivatives, and mixtures thereof. An example of a suitable N-acyl aminoacid is N-undecylenoyl-L-phenylalanine and is commercially availableunder the tradename SEPIWHITE (Registered trademark) from Seppic(France).

Skin care agents are also disclosed in US Publication No.2007/0020220A1, published Jan. 25, 2007, wherein thecomponents/ingredients are incorporated herein by reference in theirentirety.

The cosmetic composition may comprise one or more peptides. Herein,“peptide” refers to peptides containing ten or fewer amino acids, theirderivatives, isomers, and complexes with other species such as metalions (for example, copper, zinc, manganese, and magnesium). As usedherein, peptide also refers to both naturally occurring and synthesizedpeptides. In one embodiment, the peptides are di-, tri-, tetra-, penta-,and hexa-peptides, their salts, isomers, derivatives, and mixturesthereof. Examples of useful peptide derivatives include, but are notlimited to, peptides derived from soy proteins,palmitoyl-lysine-threonine (pal-KT) andpalmitoyl-lysine-threonine-threonine-lysine-serine (pal-KTTKS, availablein a composition known as MATRIXYL®)palmitoyl-glycine-glutamine-proline-arginine (pal-GQPR, available in acomposition known as RIGIN®), these three being available from Sederma,France, and Cu-histidine-glycine-glycine (Cu-HGG, also known as IAMIN®).In various embodiments the cosmetic composition may comprise from about1×10⁻⁷% to about 20%, alternatively from about 1×10⁻⁶% to about 10%, andalternatively from about 1×10⁻⁵% to about 5% of the peptide.

In one embodiment, the skin active agent is niacinamide. In oneembodiment, the agent is a combination of niacinamide, glycerine,tocopherol acetate, and D-panthenol. Niacinamide may be included in thecomposition in an amount between about 1% to about 30 wt %, in anotherembodiment from about 2% to about 28 wt %, in another embodiment fromabout 5% to about 25 w %, and in another embodiment from about 10% toabout 20 wt %. When D-panthenol is included, it may be present in anamount of about 0.5% to about 5 wt %, or about 0.5% to about 3 wt %and/or about 0.5% to about 2 wt %. Glycerin may be included as an activein an amount from about 6% to about 20 wt %, and/or from about 8% toabout 15 wt %, and/or from about 10% to about 15 wt %.

In various embodiments, the skin active agent is selected fromniacinamide, alone or in combination with one or more ofpalmitoyl-lysine-threonine,palmitoyl-lysine-threonine-threonine-lysine-serine,N-undecyl-10-enoyl-L-phenylalanine, retinyl propionate, N-acetylglucosamine, vitamin C, tretinoin, salicylic acid, benzoic acid, benzoylperoxide, tretinoin, and combinations thereof.

In an embodiment the cosmetic compositions herein may be aqueoussolutions, or emulsions such as oil-in-water emulsions, water-in-oilemulsions or multiple emulsions having aqueous or oily external phases.In another embodiment the cosmetic compositions herein are oil-in-wateremulsions.

In one embodiment to avoid a negative interaction with the pressuresensitive adhesive, the cosmetic composition comprises only low levelsof silicones of about 0.5% to about 10%, and/or from about 1% to about5% and/or the cosmetic composition is substantially free of silicones.As used herein “silicones” may refer to those silicones disclosed in US2007/0020220A1, published Jan. 25, 2007, Osborne, for example, inparagraphs [0226] to [0258].

In one embodiment the cosmetic composition is substantially free ofdepilatory agents.

The cosmetic composition may comprise an effective amount of a skinactive agent having activity to improve visual or aesthetic appearanceof the skin, such as an agent effective to reduce or diminish theappearance of fine lines and/or wrinkles on human facial skin or anagent effective to treating existing acne lesions, reducing rednessassociated with acne lesions and/or protecting from formation of acnelesions.

The methods of treatment, application, regulation, or improvementdisclosed herein may utilize the aforementioned compositions.Application of the present compositions can occur on any target area ofskin surface of the body. Skin surfaces of the most concern tend to bethose not typically covered by clothing such as facial skin surfaces,hand and arm skin surfaces, foot and leg skin surfaces, and neck andchest skin surfaces (for example, décolletage). In particular,application may be on a facial skin surface including the forehead,perioral, chin, periorbital, nose, and/or cheek skin surfaces.

The step of applying the cosmetic composition to a target area of skinmay be done by localized application to the target area, for example, anarea that contains wrinkles. In reference to application of thecomposition, the term “localized”, “local”, or “locally” mean that thecomposition is delivered to the target area of skin (such as an area ofskin containing wrinkles) while minimizing delivery to skin surface notrequiring treatment. The composition may be applied and lightly massagedinto the skin. It is recognized that localized application does allowfor a reasonable amount of the composition to be applied to areasadjacent to the wrinkles to be treated (i.e., the composition isunlikely to be applied or to remain within the boundary of the wrinkleswithout some spreading). The form of the composition or thedermatologically acceptable carrier should be selected to facilitatelocalized application. While certain embodiments of the presentinvention contemplate applying a composition locally to a wrinkled area,it will be appreciated that compositions of the present invention can beapplied more generally or broadly to one or more facial skin surfaces toreduce the appearance of wrinkles within those facial skin regions.

The method of treating skin herein may optionally begin with a cleansingstep. The consumer can wash his or her face with a suitable cleanser(for example, Olay Purifying Mud Lathering Cleanser, available from TheProcter & Gamble Company, Cincinnati, Ohio), and gently dry his or herskin with a towel.

While some methods described herein contemplate applying thecompositions of the present invention with an applicator, it will beappreciated that applicators are not required and the cosmeticcompositions of the present invention can also be applied directly byusing one's finger or in other conventional manners.

Kits

Also provided herein are kits, where the kits at least include one ormore barrier patches and a cosmetic composition comprising an effectiveamount of a skin active agent, as described herein.

Thus in an embodiment a skin care kit is provided comprising:

a cosmetic composition comprising an effective amount of a skin activeagent;one or more barrier patches comprising a backing layer having a firstsurface; a pressure sensitive adhesive in contact with the firstsurface; an adhesive release force of from about 50 gms to about 400gms; a flexibility from about 8 grams to about 40 grams; and a WVTR fromabout 1 g/m²/24 h to about 500 g/m²/24 h. The kit may comprise a displaypackage comprising a display surface or an inclined display surface,defining a first cavity to contain a cosmetic composition and a secondcavity to contain a plurality of barrier patches.

As shown in FIG. 4 a display package 2 is provided, comprising a displaysurface 7 or an inclined display surface (shown in FIGS. 5 and 6),defining a first cavity 9 to contain the cosmetic composition and asecond cavity 11 to contain a plurality of barrier patches 15.

The display package 2 may comprise a top lid 4; a bottom support tray 5having a display surface 7, defining a first cavity 9 to contain acosmetic composition (not shown) and a second cavity 11 to contain aplurality of barrier patches 15; wherein the cosmetic composition may bepositioned substantially within the first cavity 9.

In another embodiment the second cavity 11 further comprises one or moreretention tabs 17. As shown in FIG. 4 the retention tab 17 may bepositioned closer to the surface of the sheets in unit dose form 19 orthe retention tab 17 may be placed in a vertical position against thebackwall 21 of the second cavity 11 to make removal of the one or moresheets in unit dose form 19 easier to remove from the second cavity 11.

In an embodiment the display package 2 contains a plurality of sheets inunit dose form 19 wherein each sheet comprises no more than 2 barrierpatches 15, as shown in FIG. 4. Moreover, the first cavity 9 maycomprise a substantially identical dimension and/or a substantiallyidentical geometric shape of the container for the cosmetic composition.

In further embodiments shown in FIG. 4 the display package 2 may have afirst cavity 9 comprising a removal aid 23 to assist in the removal ofthe cosmetic composition from the first cavity 9. The removal aid 23 maycomprise a gap in one end of the first cavity 9 to provide an open areaso that a user may be able to insert his or her fingertip into the gapin order to remove a cosmetic composition, that is positionedsubstantially within the first cavity, from the first cavity 9.

The display package 2 may also comprise an opening tab 25 to aid inopening or closing the display package 2. The top lid 4 may furthercomprise an opening flap 27 that is configured to be seated into theclosure slot 29 when the top lid is closed. Use instructions 31 may alsobe present on the inside surface of the top lid 4. The opening tab 25may be a formed from the opening flap 27.

FIG. 5 shows another embodiment of the skin care kit 1 comprising: acosmetic composition 3 comprising an effective amount of a skin activeagent. The skin care kit further comprises a barrier patch 15 comprisinga backing layer having a first surface and a pressure sensitive adhesivein contact with the first surface; a WVTR from about 1 g/m²/24 h toabout 500 g/m²/24 h; the barrier patch optionally further comprising anadhesive release force of from about 50 gms to about 400 gms andoptionally further comprises a flexibility from about 8 grams to about40 grams.

The display package 2 of FIGS. 5 and 6 may comprise a top cover 6 havinga front wall 8, a back wall 10 (not shown) and two sidewalls 12; the topcover 6 further comprising edges 14 of the front wall 8, a back wall 10and two sidewalls 12. The display package 2 of FIGS. 5 and 6 may alsocomprise a base 18 having a front wall 20, a back wall 22 (not shown)and two sidewalls 26; an intermediate surround window 16 that may be atleast partially transparent; an inclined display surface 34, wherein theintermediate surround window 16 and the inclined display surface 34 arepositioned between said top cover 6 and said base 18. The inclineddisplay surface 34 may define a first cavity 40 to contain a cosmeticcomposition 3 and a second cavity 38 to contain a plurality of barrierpatches 15.

As shown in FIGS. 5 and 6, in an embodiment the barrier patches 15 areprovided in one or more sheet unit dose forms 44 wherein, for example,the sheet unit dose forms 44 comprise no more than 2 barrier patches 15.The second cavity 38 may also comprise one or more retention tabs 42that prevent or minimize the sheet unit dose forms from sliding out ofthe second cavity 38.

In an embodiment the cosmetic composition (or container holding thecosmetic composition) 3 may either be positioned substantially withinthe first cavity 40 wherein the first cavity is configured to house thecosmetic container, or the first cavity 40 may be configured to housethe cosmetic composition 3 in an upright position in the first cavity40. In an embodiment in FIG. 6 the first cavity 40 may further comprisea receptacle 46 which may enable the cosmetic composition (or container)to be positioned in an upright position relative to the display surfaceor the inclined display surface 34. Moreover, in the same first cavitythe cosmetic composition may also be stored in a position substantiallyparallel to the display surface or inclined display surface.

The skin care kit 1 may further comprise edges 14 of the front wall 8,back wall 10 and two sidewalls 12 of the top cover 6 that are configuredto mate with the edges 28 of the front wall 20, back wall 22 and twosidewalls 26 of the base 18 when the intermediate surround window 16 isremoved, to provide a close fitting relationship between the edges 14 ofthe top cover 6 and the edges 28 of the base 18.

In another embodiment the second cavity 38 further comprises one or moreretention tabs 42 to maintain the sheet unit dose forms 44 of thebarrier patches 15 in place so that the sheet unit dose forms of thebarrier patches do not side relative to the inclined display surface 34.

As shown in FIG. 7, in an embodiment the skin care kit 1 may compriseedges 14 of the front wall 8, back wall 10 and two sidewalls 12 of thetop cover 6 that are configured to mate with the edges 28 of the frontwall 20, back wall 22 and two sidewalls 26 of the base 18 when theintermediate surround window 16 is removed, to provide a close fittingrelationship between the edges 14 of the top cover 6 and the edges 28 ofthe base 18. The top cover 6 may be transparent or opaque.

In an embodiment the first cavity 40 comprises a substantially identicaldimension and/or geometric shape of the cosmetic composition (orcontainer) 3.

As used herein “a sheet unit dose form” means one or a plurality ofsheets (for example, continuous film sheets), that may have, forexample, from about 1 to about 6, barrier patches. Moreover, the sheetunit dose form may serve as the release layer for the barrier patch.

In an embodiment one or more barrier patches may be sealed in anindividual package so that one barrier patch or a relatively smallernumber may be removed from the packaging and used while the packaging ofany other barrier patches of the kit remain intact or un-breached.

As mentioned above, the kits may also include a cosmetic composition,for example, an aqueous cosmetic composition, comprising an effectiveamount of a skin active agent. The dosage amount of formulation providedin a kit may be sufficient for a single application or for multipleapplications. Accordingly, in certain embodiments of the subject kits asingle dosage amount of the skin active agent is present in a kit. Forexample, a kit may include a single barrier patch and a single dosageamount of the cosmetic composition.

In certain other embodiments, multiple dosage amounts of the cosmeticcomposition may be present in a kit. For example, a kit may include aplurality of barrier patches and multiple dosage amounts of the cosmeticcomposition. In those embodiments having multiple dosage amounts of thecosmetic composition, such may be packaged in a single container, forexample, a single tube, bottle, vial, and the like (as shown in FIG. 5),or one or more dosage amounts may be individually packaged such thatcertain kits may have more than one container of a cosmetic composition.In this instance the inclined display surface 34 or the display surface7 may have one or more first cavities to contain each of the cosmeticcompositions or to contain multiple cosmetic compositions. In oneembodiment the number of dosage amounts of the cosmetic composition andthe number of barrier patches are the same.

In certain other embodiments, the kit comprises multiple barrier patchesthat are of a size and shape to treat different areas of the face suchas for the treatment of age spots, the forehead, the under eye area andthe under eye area combined with the crows feet area around the eye.

The subject kits also generally include instructions for how to use thebarrier patch to occlude the cosmetic composition in order to deliverthe skin active agent to a target area of the skin. In one embodimentthe kit includes instructions to provide an effective amount of a skinactive agent to the target area of skin that will provide a layer of thecosmetic composition having a thickness from about 10 microns to about30 microns and/or from about 12 microns to about 25 microns. In anotherembodiment the kit includes instructions to provide from about 0.5mg/cm2 to about 3 mg/cm2 of the cosmetic composition, and/or from about1 mg/cm2 to about 2 mg/cm2 to the target area of skin. In one embodimentand without being bound by theory, the use of the proper amount of thecosmetic composition will minimize the interaction of the cosmeticcomposition with the pressure sensitive adhesive.

Test Methods WVTR

WVTR of the barrier patch is measured according to ASTM F1249 at 37° C.and 35% RH. Samples may be analyzed on a MOCON Permatran-W 3/33 WaterVapor Permeability Instrument using ASTM F1249. For samples with higherWVTR (for example, from approximately 300 g/m²/24 h to 500 g/m²/24 h)samples may be analyzed per ASTM E-96 with desiccant placed inside thetest cups and 35% RH surrounding the exterior of the cups. Samples ofbarrier patches are prepared and include the pressure sensitiveadhesive.

Adhesive Release Force

Adhesion measurements were evaluated with a ChemInstruments AR1000.Specimens are cut to segments 2 cm wide. One end of a 5 cm-long specimenis placed on a stainless steel test panel and rolled with a 4.5-lbhand-roller. The specimen then stays in contact with the plate for aperiod of 4 hours. The panel is placed into the instrument at 37° C. andthe other end of the specimen is attached to the grip set at a 180° peelusing Nexcare® gentle paper tape (¾″ wide) as a coupler. The speed isset to 10 in/minute and the measurement is initiated. After datacollection the initial (onset of pull) and final (pull-off) regions arediscarded and the central region where there is constant pull againstthe specimen is used to generate an average peel force. Peel forces fromthree specimens are averaged to generate a peel force for each sample.

Transparency

Transparency is measured by assessing the visibility of printed textthrough the barrier patch. The printed text is prepared by printing theEnglish alphabet (capital letters) onto transparency film (UniversalOffice Supplies) using Microsoft Word Arial font and a LaserJet 4 Plusprinter (Hewlett Packard) fitted with a black ink cartridge. Printedtransparency films are prepared in font sizes ranging from 4 points to28 points. The printed transparency films are then laid over white papersheets to ensure a uniform background and all samples assessed undernormal indoor lighting conditions, such as retail outlet lightingconditions.

The word and/or letters must be visible and/or readable by an individualusing unaided 20/20 eyesight and positioned 12 inches in front of thesample.

A sample of the barrier patch, including the backing layer and thepressure sensitive adhesive, of interest is selected. This sample isplaced, pressure sensitive adhesive side facing uppermost, onto thetransparency film printed with 4 font size. The visibility of theprinted text is assessed through the sample. If the text is not legiblethrough the sample, the sample is transferred to the next largest fontsize print and the assessment repeated. This process is repeated until afont size is reached that is legible through the sample.

The smallest font size legible through the sample is then assigned the“transparency threshold” for that device.

In one embodiment the “transparency threshold” for the sample of thebarrier patch of the present invention is no greater than about 10point, in another embodiment no greater than about 7 point and in yetanother embodiment is no greater than about 4 point.

Corneometer Testing

Improvements in skin hydration may be measured with a Corneometer, whilebaseline measurements are taken prior to application of materials. Inparticular, skin hydration based upon measurements of capacitance may beassessed using the Corneometer (Registered trademark) 825. Use of aCorneometer is further described in U.S. patent application Ser. No.13/007,630. Such measurements can be non-invasive and can be taken induplicate on the target area of skin at the following times: Atbaseline, and 8 hours post-treatment.

Data can be recorded electronically using direct data entry and datacapture programs. Measurements can be performed according to a testfacility's standard operating procedures and/or the Instrument OperationManual.

The Corneometer values are arbitrary units for electrical impedance. Atbaseline, for subjects having a dry skin grade from about 2.5 to about4.0, an adjusted mean of such Corneometer values can typically fallwithin a range of about 15 to about 20. Higher Corneometer values cancorrespond to a higher hydration level, and thus, lower Corneometervalues can correspond to lower hydration levels. The same instrument(s)and operator(s) can be used throughout the study.

The probe can be wiped with a Kimwipe between each measurement. At theend of an evaluation session, data collected for that period can bebacked up according to instructions in the Instrument Operation Manual,and a hard copy of the data can be printed.

Flexibility

Rigidity or flexibility is measured using a Handle-O-Meter, model #211,available from Thwing-Albert Instrument Co. of Philadelphia, Pa. A 100-gbeam was used. For the sample, a specimen was cut to a square of 50 mmwidth and length. The specimens should be cut in each of the principledirections of the sample, avoiding creases and wrinkles. The samples aretested in four positions (one in each direction and one on each side ofthe sample), with an average rigidity reported for the 4 positions. Forsamples with adhesive material, a 1 mil polyethylene film was attachedto the sample to cover the adhesive. To account for the effect onflexibility of the 1 mil polyethylene film used as a cover, theflexibility of the 1 mil film was tested separately. This flexibilityvalue was then subtracted from the flexibility value of the samplewithout the cover film. For thicker samples, it may be necessary to cutsamples with dimensions smaller that 50 mm×50 mm to allow theHandle-O-Meter to be able to depress the samples into the slot.

EXAMPLES

The following are non-limiting examples of compositions of the presentinvention. The examples are given solely for the purpose of illustrationand are not to be construed as limitations of the present invention, asmany variations thereof are possible without departing from the spiritand scope of the invention, which would be recognized by one of ordinaryskill in the art.

In the examples, all concentrations are listed as weight percent, unlessotherwise specified and may exclude minor materials such as diluents,filler, and so forth. The listed formulations, therefore, comprise thelisted components and any minor materials associated with suchcomponents. As is apparent to one of ordinary skill in the art, theselection of these minors will vary depending on the physical andchemical characteristics of the particular ingredients selected to makethe present invention as described herein.

Examples 1-5

Example 1 2 3 Phase A Distilled water qs 100 qs 100 qs 100 Phase BGlycerin 5 5 5 Ti02 0.75 0.75 0.75 Phase C glycerin 1 1 1 EDTA 0.1 0.10.1 Carbopol 954 0.68 0.5 0.5 Carbopol 1382 0.1 0.1 0.1 Phase D CetylAlcohol 0.72 0.72 0.72 Stearyl Alcohol 0.48 0.48 0.48 Stearic Acid 0.10.1 0.1 PEG-100 Stearate 0.1 0.1 0.1 Arlatone 2121 1 1 1 Silicone Q214032 2 2 Fatty acid ester of sugar 0.67 0.67 0.67 Tocopherol Acetate 0 00.5 Niacinamide 2 2 2 Phase E distilled water 2 2 2 NaOH to neutralizeCarbopols to neutralize to neutralize to neutralize Phase F Urea 2 0 0D-Panthenol 0 0 0.5 distilled water 5 5 5 Phase G Glydant Plus 0.1 0.10.1 Glycerin 1 1 1 distilled water 1 1 1 Phase H Methyl Isostearate 1.330 0 Isopropyl Isostearate 0 1.33 1.33 Retinol 0 0 0.04 BHT 0 0 0.05Tween 20 0 0 0.04 Example 4 5 Phase A distilled water qs 100 qs 100Phase B Glycerin 6 6 Ti02 0.75 0.75 Phase C Glycerin 3 3 Carbopol 9540.4 0.4 EDTA 0.1 0.1 Phase D Cetyl Palmitate 1.5 1.5 Cetyl Alcohol 2.252.25 Stearyl Alcohol 1.5 1.5 Stearic Acid 0.31 0.31 PEG-100 Stearate0.31 0.31 Silicone Wax DC2501 2 2 DC 3225C 1.88 1.88 Dimethicone 200/350cst 0.63 0.63 Tocopherol Acetate 0 0.5 Niacinamide 2 2 Phase E distilledwater 2 2 NaOH to neutralize Carbopol to neutralize to neutralize PhaseF D-Panthenol 0 0.5 distilled water 0 5 Phase G Glydant Plus 0.1 0.1distilled water 1 1 glycerin 1 1 Phase H Isopropyl Palmitate 1.25 1.25Retinol 0 0.04 Tween 80 0 0.04 BHT 0 0.05

Oil-in-water emulsions are prepared from the ingredients in theseexamples using conventional formulating techniques. First, sparge PhaseA ingredients using nitrogen for approximately 15 minutes. Phase Bingredients are milled until the Ti02 is homogeneously dispersed, andthen added to Phase A. Phase C ingredients are then dispersed into PhaseA/B until uniform using propeller type mixing and heating the mixture toabout 75° C. In a separate vessel, Phase D ingredients are combined andheated to about 75° C. The mixture of phases A/B/C are then blanketedwith a slow, steady stream of nitrogen. Next the Phase D ingredients arehomogenized into the mixture of phases A/B/C using any rotor/stator typeof homogenizer for approximately 15 minutes. After the 15 minutes, themixing is switched to low rpm sweep mixing. Next, phase E ingredientsare combined and added to the mixture of phases A-D.

Once phase E is mixed and the batch mixture is homogeneous, the entirebatch mixture is cooled. When the 5 batch is cooled to about 50° C.,phase F ingredients are added and homogenized. When the batch is cooledto about

40° C., phase G ingredients are added to the batch mixture. Lastly, whenthe batch mixture is cooled to about 30° C., the phase H ingredients arecombined to the batch mixture. Mixing is continued until the batchmixture is uniform.

Delivery of Skin Active Agent to a Target Area of Skin.

The above compositions 1, 2, 3, 4 and/or 5 are applied via thefingertips to the periorbital area of the face of a human test subjectto provide from about 0.5 mg/cm2 to about 3 mg/cm2 of the cosmeticcomposition to the target area of skin. Thereafter an exemplary orbitalbarrier patch for treatment of periorbital skin aging is attached toperiorbital area, covering the cosmetic composition. The barrier patchis transparent and comprises an adhesive release force of about 150grams, a WVTR of about 3 g/m²/24 h, and a flexibility of about 10 grams.The barrier patch of the invention is applied and worn for an extendedperiod of time of approximately 7-8 hours and thereafter removed. Themethod herein delivers an effective amount of the skin active agent in amanner that achieves penetration of the skin active agent into thestratum corneum, and/or other layers of the epidermis, and in manyembodiments, into the basal skin layer and/or dermis.

Example 6

A consumer, small-base paired comparison of a patch prototype, 3M 1525L(C), against a series of other commercial patch materials was conducted.The commercial patch materials varied in WVTR, flexibility and adhesiverelease force values as indicated below in Table 2. The materialsincluded 9776, 9904, 9916, 2476P and 2475P, available from 3M.

Each consumer applied a cosmetic composition. Olay Anti Wrinkle ResultsEye Cream, via the fingertips to the periorbital area of their facedelivering approximately from 0.5 mg/cm² to 3 mg/cm² of the cosmeticcomposition to the target area of skin. After applying the cosmeticcomposition, the test subjects applied one of the barrier patches listedbelow and adhered it to the periorbital area, covering or overlappingthe cosmetic composition. The barrier patch was worn for approximately7-9 hours, generally overnight while sleeping, and thereafter removed.This regimen was repeated for each of five consecutive days. Thenconsumers answered a questionnaire about the comfort, ease of use andperformance of the product.

TABLE 2 Patch 1525L 9776 9904 9916 2476P 2475P (Sample C) (Sample U)(Sample X) (Sample R) (Sample S) (Sample T) Thickness 4.4 34 11 15 14.64.6 (mil) Backing Polyethylene Polyethylene Polyurethane SpunlaceSpunlace Thermoplastic Layer nonwoven polyester elastomer AdhesiveAcrylate Acrylate Acrylate Acrylate Silicone Silicone Handle-O- 14.2106.5 24.9 40.4 13.4 5.5 Meter (g) Peak 352.4 387.5 784 2441 108 77.3Adhesion (g) WVTR 2.6 15 79 813 225 198 (g/m2-day) Overall Rating¹Sample C-51 Sample C-36 Sample C-50 Sample C-52 Sample C-55 Sample C-60Sample U-48 Sample X-41 Sample R-42 Sample S-52 Sample T-35 ¹For theoverall ratings, each Sample was rated and compared to Sample C.

Consumers prefer, via the overall rating score, 1525L having an adhesiveforce of 352.4 g, a flexibility of 14.2, and a WVTR of 2.6, to all ofthe other patches with the exception of 9776. However, 9776 hadsignificantly higher stiffness than 1525L having a flexibility of 106.5and consumers rated 9776 less comfortable to wear. 2475P, the mostflexible patch, had the lowest score. It was difficult to handle andapply by consumers.

Thus providing barrier patches with the right balance of adhesion,flexibility, and WVTR properties provides preferred product attributes.Water Vapor Transmission Rate provides a degree of occlusion and skinhydration; proper flexibility allows the barrier patch to conform toface and not interfere with sleep, while easy to handle and apply; andproper adhesion keep the barrier patch in place, feels comfortable, andis easily removed.

The dimensions and values disclosed herein are not to be understood asbeing strictly limited to the exact numerical values recited. Instead,unless otherwise specified, each such dimension is intended to mean boththe recited value and a functionally equivalent range surrounding thatvalue. For example, a dimension disclosed as “40 mm” is intended to mean“about 40 mm.”

Every document cited herein, including any cross referenced or relatedpatent or application and any patent application or patent to which thisapplication claims priority or benefit thereof, is hereby incorporatedherein by reference in its entirety unless expressly excluded orotherwise limited. The citation of any document is not an admission thatit is prior art with respect to any invention disclosed or claimedherein or that it alone, or in any combination with any other referenceor references, teaches, suggests or discloses any such invention.Further, to the extent that any meaning or definition of a term in thisdocument conflicts with any meaning or definition of the same term in adocument incorporated by reference, the meaning or definition assignedto that term in this document shall govern.

While particular embodiments of the present invention have beenillustrated and described, it would be obvious to those skilled in theart that various other changes and modifications can be made withoutdeparting from the spirit and scope of the invention. It is thereforeintended to cover in the appended claims all such changes andmodifications that are within the scope of this invention.

What is claimed is:
 1. A skin care kit comprising: a cosmeticcomposition comprising an effective amount of a skin active agent; abarrier patch comprising a backing layer having a first surface and apressure sensitive adhesive in contact with the first surface; thebarrier patch comprising an adhesive release force of from about 50 gmsto about 400 gms; a flexibility from about 8 grams to about 40 grams;and a WVTR from about 1 g/m²/24 h to about 500 g/m²/24 h; a displaypackage comprising: a display surface or an inclined display surface,defining a first cavity to contain the cosmetic composition and a secondcavity to contain a plurality of barrier patches.
 2. The kit of claim 1wherein the adhesive release force is about 100 grams to about 200grams.
 3. The kit of claim 1 wherein the WVTR is about 1 g/m²/24 h toabout 250 g/m²/24 h.
 4. The kit of claim 3 wherein the WVTR is about 2g/m²/24 h to about 20 g/m²/24 h.
 5. The kit of claim 1 wherein thebarrier patch is water impermeable.
 6. The kit of claim 1 wherein thebarrier patch has a thickness of about 3 mils to about 15 mils.
 7. Thekit of claim 6 wherein the barrier layer has a thickness of about 2 milsto about 15 mils and the adhesive has a thickness of about 1 mils toabout 5 mils.
 8. The kit of claim 1 wherein the flexibility is fromabout 8 grams to about 25 grams.
 9. The kit of claim 1 wherein thepressure sensitive adhesive is selected from the group consisting ofacrylic and methacrylic ester homo- or copolymers, butyl rubber basedsystems, silicones, urethanes, vinyl esters and amides, olefin copolymermaterials, and combinations thereof.
 10. The kit of claim 1 wherein thebarrier patch is substantially free of skin active agent.
 11. The kit ofclaim 1 wherein the cosmetic composition and barrier patch are designedto remain in contact with the target area of skin for a period of timefrom about 4 hours to about 24 hours.
 12. The kit of claim 1 whereinbarrier patch provides a hydration value from about 35 to about
 120. 13.The kit of claim 1 wherein the barrier patch further comprises a releaselayer on the surface of the pressure sensitive adhesive and opposite thebacking layer.
 14. The kit of claim 1 wherein the cosmetic compositioncomprises from about 0.01% to about 10% by weight of vitamin B.
 15. Thekit of claim 14 wherein the cosmetic composition further comprisesniacinamide, glycerine, tocopherol acetate, D-panthenol, andcombinations thereof.
 16. The kit of claim 1 wherein the skin activeagent comprises from about 0.01% to about 10% of a skin active agentselected from the group consisting of vitamin E, vitamin A,palmitoyl-lysine-threonine,palmitoyl-lysine-threonine-threonine-lysine-serine,N-undecyl-10-enoyl-L-phenylalanine, retinyl propionate, N-acetylglucosamine, vitamin C, tretinoin, salicylic acid, benzoic acid, benzoylperoxide, tretinoin, and combinations thereof.
 17. The kit of claim 1wherein the barrier patch is essentially free of a non-woven material.18. The kit of claim 1 wherein the second cavity further comprises oneor more retention tabs.
 19. The kit of claim 1 wherein the barrierpatches are provided in sheet unit dose form.
 20. The kit of claim 19wherein the sheet unit dose form comprises no more than 2 barrierpatches.
 21. The kit of claim 1 wherein the cosmetic composition ishoused in a container and the first cavity comprises a substantiallyidentical dimension or geometric shape of the cosmetic compositioncontainer.
 22. The kit of claim 1 wherein the first cavity furthercomprises a removal aid to assist in the removal of the cosmeticcomposition container from the first cavity.
 23. The kit of claim 1wherein the display package further comprises: a top cover having afront wall, a back wall and two sidewalls; a base having a front wall, aback wall and two sidewalls; an intermediate surround window positionedbetween said top cover and said base.
 24. The kit of claim 1 wherein thecosmetic composition may either be positioned substantially within thefirst cavity or positioned in an upright position in the first cavity.25. The kit of claim 23 wherein the edges of the front wall, back walland two sidewalls of the top cover are configured to mate with the edgesof the front wall, back wall and two sidewalls of the base when theintermediate surround window is removed to provide a close fittingrelationship.
 26. The kit of claim 1 wherein the display package furthercomprises a top cover having a front wall, a back wall and two sidewallswherein the front wall further comprises an opening tab.
 27. The kit ofclaim 1 wherein display package further comprises an opening tab to aidin opening or closing the display package.
 28. The kit of claim 27wherein the display package further comprises a top lid comprising anopening flap that is configured to be seated into a closure slot whenthe top lid is closed.